NAD+
Price range: $144.00 through $238.00
NAD+ (nicotinamide adenine dinucleotide) is the central redox coenzyme studied for sirtuin activity, DNA repair, and mitochondrial energy metabolism. See mechanism and specifications.
Description
NAD+ – Nicotinamide Adenine Dinucleotide Research Compound
Nicotinamide adenine dinucleotide (NAD+) is the central redox coenzyme of cellular metabolism. It is a small molecule – not a peptide – that cycles between an oxidized form (NAD+) and a reduced form (NADH) as it shuttles electrons through glycolysis, the TCA cycle, and the mitochondrial electron transport chain. In research, NAD+ is the reference substrate for an entire family of enzymes: sirtuins (SIRT1-SIRT7), PARPs (DNA repair), and CD38 (calcium signaling). Cellular NAD+ levels decline measurably with age across tissues, which is the observation that anchors the large body of NAD+-restoration research.
Why the Redox + Sirtuin Substrate Role Matters
NAD+ has two distinct research axes. The classical role is redox cofactor – it accepts electrons from fuel metabolism and hands them to the electron transport chain, which is the mechanism that links NAD+ to mitochondrial ATP output. The second role, characterized more recently, is substrate for NAD+-consuming enzymes (sirtuins, PARPs, CD38). Sirtuins require NAD+ to deacetylate histones and other protein targets, which is how NAD+ feeds into longevity, DNA repair, and stress-response research axes. That second role is why NAD+ shows up in aging research rather than just metabolism research.
| Pathway | What it does in plain terms |
|---|---|
| Redox coenzyme (NAD+ / NADH) | Electron shuttle – glycolysis, TCA cycle, electron transport chain |
| Sirtuin substrate (SIRT1-SIRT7) | Required for histone / protein deacetylation – longevity and stress-response axis |
| PARP substrate | Required for poly-ADP-ribosylation – DNA damage repair |
| CD38 | Consumes NAD+ – primary driver of age-related NAD+ decline |
| Mitochondrial biogenesis | SIRT1-PGC1α axis drives mitochondrial expansion and oxidative capacity |
NAD+ vs NMN vs NR
Three related compounds show up constantly in NAD+-restoration research. They differ in their position in the NAD+ biosynthetic pathway.
| Compound | Research axis |
|---|---|
| NAD+ | Terminal coenzyme – direct substrate for sirtuins, PARPs, CD38 |
| NMN | Direct NAD+ precursor – one enzymatic step away (NMNAT catalyzes NMN → NAD+) |
| NR | Upstream precursor – two enzymatic steps (NR → NMN → NAD+) |
Research Applications
NAD+ is used in studies examining:
- Sirtuin-mediated deacetylation and longevity-axis endpoints
- Mitochondrial energy metabolism and oxidative capacity
- DNA damage repair via PARP pathway activation
- Age-related NAD+ decline restoration research
- Neurodegenerative disease models (Parkinson’s, Alzheimer’s)
- Metabolic health and insulin sensitivity endpoints
Specifications
| Format | Lyophilized powder |
| Purity | ≥99% |
| Molecular class | Small molecule coenzyme (not a peptide) |
| Aliases | NAD+, NAD, Nicotinamide Adenine Dinucleotide, β-NAD+ |
| Available sizes | 500mg |
| Storage | 2-8°C unopened, protected from light; stable 12+ months |
| Use | Research purposes only – not for human use |
Storage & Handling
Unopened vials are kept at 2-8°C under standard cold-chain conditions and remain stable for 12+ months. Reconstitution parameters, solvent compatibility, and post-reconstitution stability for NAD+ are documented in the published peer-reviewed literature and standard peptide-chemistry references.
Reference Literature
Published clinical and preclinical NAD+ literature is available through PubMed, Google Scholar, and other peer-reviewed databases. WWP does not provide protocol design, dosing guidance, or administration parameters. Those decisions rest with the researcher and any applicable institutional review board.
Common Questions About NAD+ Research
What is NAD+ used for in research?
It is studied as the central redox coenzyme and substrate for sirtuins, PARPs, and CD38. Published work covers sirtuin-mediated longevity endpoints, mitochondrial energy metabolism, DNA damage repair, age-related NAD+ decline restoration, and neurodegenerative disease models.
Is NAD+ a peptide?
No. NAD+ is a small-molecule coenzyme composed of two nucleotides (nicotinamide mononucleotide and adenosine monophosphate) joined through their phosphate groups. It is not a peptide, but it appears in the research toolkit alongside peptides because its metabolic, longevity, and mitochondrial-function research axes overlap with peptide research.
What is the difference between NAD+, NMN, and NR?
NMN and NR are precursors that the body con
Is NAD+ FDA approved?
No. NAD+ is not an FDA-approved drug product. It is widely available as a research compound and as a supplement ingredient, but there is no approved pharmaceutical NAD+ product. Every vial WWP ships is labeled and sold strictly for laboratory and research use only.
How is NAD+ stored?
Unopened vials are stored at 2-8°C protected from light and stay stable for 12+ months. Once reconstituted with bacteriostatic water, the solution should be kept at 2-8°C protected from light and used within 14-21 days because of oxidation sensitivity.
Purity Guarantee
Every batch is ≥99% purity. Send us a COA from any independent test and we’ll issue store credit regardless of what it shows.
Additional information
| Milligrams Per Vial | 500 mg, 1000 mg |
|---|
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